Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the framework and dynamics of chromosomes. Our analysis interests involve:
Our team experiments bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our main curiosity lies in cell division, chromatin structure, and spatial Manage.
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However, For some time just after Iijima’s report, the production of clean nanotubes was cumbersome. In 1996, nonetheless, the group of Richard Smalley at Rice University managed to supply solitary-walled carbon nanotubes at substantial produce. Soon soon after, I contacted Smalley, and we made a decision to be part of forces to evaluate the transport via a single carbon nanotube.
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style in 2005. (nl)
SMC complexes can pass Actual physical roadblocks bigger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion
Many similar developments adopted, in which our group founded diverse transistor variants including single-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into little evidence-of-theory electronic circuits.
Example (1) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is demonstrated in gray, the rim of the pore is highlighted in crimson, plus a 3D rendering of your motion from the DNA rod is shown.
The rotors harness Electrical power from the nanoscale water and ion move that is certainly generated by a static chemical or electrochemical opportunity gradient from the nanopore, which can be established via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, cees dekker suggesting methods to developing Strength-transducing motors at nanoscale interfaces.
It was during this era that Dekker carried out investigate on magnetic spin devices and on noise in superconductors and semiconductors.
Testing pseudotopological and nontopological models for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments
Many new phenomena ended up found, and he and his investigate group established a number one position With this area of investigate. Dekker and his analysis team identified new physics of nanotubes and explored the feasibility of molecular electronics. In 1998, they have been the first to create a transistor based on an individual nanotube molecule.
One example is, we think about the nucleopore intricate, a gateway among the mobile nucleus plus the cytoplasm. This is an extremely complicated procedure and for that reason hard to analyze in the cell, so we use biomimetics. We reconstruct holes after which you can insert specific components of the nucleopore advanced to study transportation via it at The one-molecule degree.’
‘I'm pushed by speculate and thoughts. On a material level I discover solutions in physics, but I expertise my deepest pleasure with God. That religion also drives my science And just how I manage people today.